The big characters who occupy science, especially modern science, are all "off" in fundamental ways. I don't think that genius goes hand in hand with being socially inept or being a sociopath or being a misanthrope, but I do think that it is a mind that can think so differently - so beyond how one is supposed to think. I wanted to pay tribute to that mind.

I'm an indulgent writer - I'm not sure, however, that's something I'm interested in changing. Writing should be indulgent: you should take big risks on the page, you should make big mistakes, you should be excessive at times. I let myself do as a writer what I probably would be less likely to allow as an editor.

I was fortunate because I had parents who believed that being a writer was a perfectly acceptable thing to want to be. They'd actually hoped that I might be an artist, and I was lucky again to grow up with people who delighted in making things: my father wove baskets and painted furniture and carved wood figures; my mother quilted and embroidered and sewed.

Of death, my father has always said that the best conditions are the ones in which you have plenty of time to prepare - to say what you need to say; to arrange your estate - and the ones in which you get to choose, or at least have some knowledge of, how and when it might happen. One can't elude death, but one can have a good death.

We're living in a literary age, at least in America, that is marked by a sense of distance, a coolness, in all senses of that word. To be too obviously, unapologetically emotional is to risk being considered foolish, or at the very least not serious.

There are times I wish I didn't have a job, even though I love my job: I get to work with interesting, eccentric colleagues and equally interesting and eccentric subject matter, both of which are rarities. But, naturally, I would treasure having more freedom someday: of time and of movement. Will I always have a full-time job? I don't know. But I do know that I need to spend at least part of my week in an office, with other people.

Many writers write across difference of one kind or another. Sometimes the difference is large and recognizable: gender, or race, or religion, or sexuality. And sometimes the differences are smaller. ... Where authors get into trouble is in trying to make those different characters stand in for whole groups of people, or for creating characters only to fetishize or explore their supposed otherness. Your character can be wildly different from you, as long as he's written with respect and, moreover, specificity.