The big characters who occupy science, especially modern science, are all "off" in fundamental ways. I don't think that genius goes hand in hand with being socially inept or being a sociopath or being a misanthrope, but I do think that it is a mind that can think so differently - so beyond how one is supposed to think. I wanted to pay tribute to that mind.

Many writers hate the shilling process, and I understand that. However, it's really the only thing about the publication process you can somewhat control. You can't affect reviews. But you can try to find your book an audience. One of the problems with the book publishing industry is that their publicity efforts tend to be spent on people who already read, and know how to discover, literary fiction.

When you're 21 you think, "Old people sound like this. Old people think like this." I don't think my ideas about aging and about eternal life changed that much, but it became more poignant to me as I did get older and I could better imagine, as you sort of inch closer to death every day, why legacy, more than aging, becomes important to people.

We're living in a literary age, at least in America, that is marked by a sense of distance, a coolness, in all senses of that word. To be too obviously, unapologetically emotional is to risk being considered foolish, or at the very least not serious.

Now, almost twenty years since my last job in book publishing, I know that there are far more socially inept people in book than in magazine publishing. At the time, however, I just didn't feel I was enough: smart enough, savvy enough, well read enough, educated enough, charming enough. Much of this was probably because I was very naive, and didn't really know how to behave in an office. This made me a terrible assistant, which in turn made me a terrible junior book editor.

I always wanted to be a scientist. I don't really have any writer friends. The process of being a writer is much more interior than being a scientist, because science is so reactionary. I think that all research scientists think of themselves as belonging to a grand tradition, building on work that has been worked on since the very beginning of science itself. Whereas I'm not sure writers think of themselves in the same way.

I was fortunate because I had parents who believed that being a writer was a perfectly acceptable thing to want to be. They'd actually hoped that I might be an artist, and I was lucky again to grow up with people who delighted in making things: my father wove baskets and painted furniture and carved wood figures; my mother quilted and embroidered and sewed.