When you want to be a writer, you think that actually getting published will make you feel somehow more real to yourself. But it doesn't. And nor should it. If publication is the pole around which your entire identity pivots, you're in big trouble. I'd also add that many wonderful books by brilliant authors get ignored or overlooked, and that poor sales aren't (necessarily) a measure of your abilities.

I've never really understood the desire to be immortal myself. The idea of both wanting to live forever in some form and wanting to stay young forever just sounds exhausting. It's one of those desires that people think they want but when you actually stop to think about what it actually means, it's really awful. One of the reasons that life is bearable is because it's going to end soon. One of the main concerns of fiction is how do we make a life of 85 years or so meaningful.

We're living in a literary age, at least in America, that is marked by a sense of distance, a coolness, in all senses of that word. To be too obviously, unapologetically emotional is to risk being considered foolish, or at the very least not serious.

To be a scientist you have to be willing to live with uncertainty for a long time. Research scientists begin with a question and they take a decade or two to find an answer. Then the answer they get may not even answer the question they thought it would. You have to have a supple enough mind to be open to the possibility that the answer sometimes precedes the question itself.

I credit my parents for many things that had never seemed remarkable when I was growing up, and one of those things is how nonthreatened they were by my constant search for backup parents - other mothers and fathers would have bristled at this, but they never did. So I was always looking for other parental stand-ins, and I always found them.

I wanted to write about the time when science became modern, around the 1950s. Right after physicist J. Robert Oppenheimer, science started being so politicized and used as such a political weapon. When my father, who is a scientist, tells me about those years, I get a competing portrait of people who were expected to behave normally and be decent respectable members of society and who were also allowed this freedom to think in big and expansive ways. Now, when you think about people who work in labs, they're allowed to be socially inept in a very fundamental way.

When you're 21 you think, "Old people sound like this. Old people think like this." I don't think my ideas about aging and about eternal life changed that much, but it became more poignant to me as I did get older and I could better imagine, as you sort of inch closer to death every day, why legacy, more than aging, becomes important to people.