I think American films right now are suffering from an excess of scale. Lots of movies we're seeing now are more akin to video games than stories about human life and relationships. Twelve- to 20-year-olds are maybe the largest economic force in the US movie business. I'm not a very nostalgic person - but I enjoy a good story.

Our health relies entirely on the vitality of our fellow species on Earth.

My ambition from the very beginning was to make a good part for myself, something differently to what lately I've been doing.

Work hard and figure out how to be useful and don't try to imitate anybody else's success. Figure out how to do it for yourself with yourself.

You know you're getting old when all the names in your black book have M. D. after them.

Never again will I allow our political self-interest to deter us from doing what we know to be morally right. Atrocity and terror are not political weapons. And to those who would use them, your day is over. We will never negotiate. We will no longer tolerate and we will no longer be afraid. It's your turn to be afraid.

Because the character is a fiction, he's a composite of other contributors to the science that brought this enzyme therapy through the process. We had the opportunity to make him up out of those things that helped tell the story. We wanted to create both ally and antagonist for John [in the Extraordinary measures].