I prefer to be part of a positive statement. I'm not interested in the psyche of a serial killer. What I'm interested in is creating a situation in which people get some emotional exercise, which makes them feel like human beings and makes them understand that they are part of the human community with all its responsibilities.

The capacity to create [visual] effects in the computer has made the job easier, but it has also introduced the complexity that you can with a few more keystrokes generate such a busy canvas that the eye doesn't know where to go. You lose human scale on an event and you're just wowed by the kinetics and the visualization. But, often in those cases I feel you lose touch with the human characters and what it is that they would feel and how they might feel, and that's still the most important part.

I have children. I have other concerns. I have other focuses. I really feel very sympathetic and I would love to be able to help but I don't see this as the opportunity, having done 'Extraordinary measures', for me to suddenly leap on a soap box and begin to talk about the pharmaceutical industry or the desperate plight of sick children. I do what I can in my world but I don't have the bona fides to do that right now.

When we protect the places where the processes of life can flourish, we strengthen not only the future of medicine, agriculture and industry, but also the essential conditions for peace and prosperity.

I think that the best movies are made, not from a point of view that depends on your personal history, whether it's the color of your skin or the politics that you had or the place that you come from, but from a point of view of an understanding of human nature, an understanding of history, and an understanding of what motivates people.

My ambition from the very beginning was to make a good part for myself, something differently to what lately I've been doing.

I had the idea that the film would be much better served by a Branch Rickey lookalike than a Harrison Ford lookalike. I didn't want the audience to go into the film thinking that they knew me from some previous experience in a movie.