I can't imagine how American readers will react to a novel, but if the story is appealing it doesn't matter much if you don't catch all the detail. I'm not too familiar with the geography of nineteenth century London, for instance, but I still enjoy reading Dickens.
Haruki MurakamiAccording to Chekhov," Tamaru said, rising from his chair, "once a gun appears in a story, it has to be fired." "Meaning what?" "Meaning, don't bring unnecessary props into a story. If a pistol appears, it has to be fired at some point. Chekhov liked to write stories that did away with all useless ornamentation.
Haruki Murakami