Religious bondage shackles and debilitates the mind and unfits it for every noble enterprise.... During almost fifteen centuries has the legal establishment of Christianity been on trial. What have been its fruits? More or less, in all places, pride and indolence in the clergy; ignorance and servility in laity; in both, superstition, bigotry, and persecution.

Ecclesiastical establishments tend to great ignorance and corruption

Every answer he [President John Adams] gives to his addressers unmasks more and more his principles and views. His language to the young men at Philadelphia is the most abominable and degrading that could fall from the lips of the first magistrate of an independent people, and particularly from a Revolutionary patriot.

Conscience is the most sacred of all property; other property depending in part on positive law, the exercise of that being a natural and unalienable right. To guard a man's house as his castle, to pay public and enforce private debts with the most exact faith, can give no title to invade a man's conscience, which is more sacred than his castle, or to withhold from it that debt of protection for which the public faith is pledged by the very nature and original conditions of the social pact.

What is government itself but the greatest of all reflections on human nature?

There is not a more important and fundamental principle in legislation, than that the ways and means ought always to face the public engagements; that our appropriations should ever go hand in hand with our promises. To say that the United States should be answerable for twenty-five millions of dollars without knowing whether the ways and means can be provided, and without knowing whether those who are to succeed us will think with us on the subject, would be rash and unjustifiable. Sir, in my opinion, it would be hazarding the public faith in a manner contrary to every idea of prudence.

The advancement and diffusion of knowledge is the only guardian of true liberty.