The vexing thing about human behavior is that when we say we know we should do something, we really and truly do know it. It's hard to be 50 lbs. overweight or smoke a pack a day or feel miserable every moment you spend at work and not understand in a deep and primal way that change is in order - and that in some cases it could even save your life.

It's not mere extremism that makes folks at the fringes so troubling; it's extremism wedded to false beliefs. Humans have long been dupes, easily gulled by rumors and flat-out lies.

There are a lot of downsides to being male. We age faster and die younger. But give us this: we're lifetime baby-making machines. Women's reproductive abilities start to wane when they're as young as 35. Men? We're good to go pretty much till we're dead.

What people fear most about tragedy is its randomness - a taxi cab jumps the curb and hits a pedestrian, a gun misfires and kills a bystander. Better to have some rational cause and effect between incident and injury. And if cause and effect aren't possible, better that there at least be some reward for all the suffering.

Everybody loves to spend money at least some of the time - because everybody loves the stuff you can buy with it. The key to the pleasure level of any transaction is the balance between the pain of the payment and the reward of the purchased object.

Narcissism falls along the axis of what psychologists call personality disorders, one of a group that includes antisocial, dependent, histrionic, avoidant and borderline personalities. But by most measures, narcissism is one of the worst, if only because the narcissists themselves are so clueless.

As MBA professors endlessly tell their students, companies do best when they stick to what they do well. There's a reason Apple doesn't make blenders. There's a reason Haagen-Dazs doesn't sell meat. And there's a reason drug companies should focus on saving and improving lives - not jeopardizing them.