Spare a thought for the poor introverts among us. In a world of party animals and glad-handers, they're the ones who stand by the punch bowl. In a world of mixers and pub crawls, they prefer to stay home with a book. Everywhere around them, cell phones ring and e-mails chime and they just want a little quiet.

Suffering is always hard to quantify - especially when the pain is caused by as cruel a disease as Alzheimer's. Most illnesses attack the body; Alzheimer's destroys the mind - and in the process, annihilates the very self.

The vexing thing about human behavior is that when we say we know we should do something, we really and truly do know it. It's hard to be 50 lbs. overweight or smoke a pack a day or feel miserable every moment you spend at work and not understand in a deep and primal way that change is in order - and that in some cases it could even save your life.

Every batch of sperm represents an opportunity for genetic typos - called de novo mutations - to be passed on. A 20-year-old man and woman will each pass on about 20 de novo mutations to a baby they conceive. By the time the couple is 40, a woman's total has remained at 20, while a man's has jumped to 65 - and it keeps climbing from there.

Overspending is as certain a part of the holiday season as overeating. But pushing away from both the table and the cash register at least a little bit sooner can make the post-holiday hangover hurt a little bit less.

Toxins love to get you while you're young. Lead, mercury, secondhand smoke and sundry other environmental nasties do a lot more damage when tissue is immature, vulnerable and growing than when it's mature and comparatively fixed.

Is there anything sadder than the foods of the 1950s? Canned, frozen, packaged concoctions, served up by the plateful, three meals per day, in an era in which the supermarket was king, the farmer's market was, well, for farmers, and the word 'locavore' sounded vaguely like a mythical beast.