Hope can be imagined as a domino effect, a chain reaction, each increment making the next increase more feasible... There are moments of fear and doubt that can deflate it.

There is an authentic biology of hope. Belief and expectation - the key elements of hope - can block pain by releasing the brain's endorphins and enkephalins, mimicking the effects of morphine.

False hope can lead to intemperate choices and flawed decision making. True hope takes into account the real threats that exist and seeks to navigate the best path around them.

Help, then, is the ballast that keeps us steady, that recognizes where along the path are the dangers and pitfalls that can throw us off; hope tempers fear so we can recognize dangers and then bypass or endure them.

I had learned that every patient has the right to hope, despite long odds, and it was my role to help nurture that hope.

Hope, true hope, has proved as important as any medication I might prescribe or any procedure I might perform.

I feel that I have to do everything better just to be judged as okay. It is something I wish I could let go of. It's something that I wish just wasn't there.