I don't begin a novel or a screenplay until I know the ending. And I don't mean only that I have to know what happens. I mean that I have to hear the actual sentences. I have to know what atmosphere the words convey.

Anyone can be sentimental about the nativity; any fool can feel like a Christian at Christmas. But Easter is the main event; if you don’t believe in the resurrection, you’re not a believer." “If you don’t believe in Easter,” Owen Meany said. “Don’t kid yourself—Don’t call yourself a Christian.

If you don't feel that you are possibly on the edge of humiliating yourself, of losing control of the whole thing, then probably what you are doing isn't very vital.

Kids are perfect people till grownups get their hands on them.

I suppose I'm proudest of my novels for what's imagined in them. I think the world of my imagination is a richer and more interesting place than my personal biography.

Owen Meany believed that “coincidence” was a stupid, shallow refuge sought by stupid, shallow people who were unable to accept the fact that their lives were shaped by a terrifying and awesome design – more powerful and unstoppable than the Yankee Flyer. (a train)

Know the story before you fall in love with your first sentence. If you don’t know the story before you begin the story, what kind of a storyteller are you? Just an ordinary kind, just a mediocre kind – making it up as you go along, like a common liar.