You have to decide what those issues are for you. What do you think disqualifies a person from holding public office? I believe that the endorsement of the right to kill unborn children disqualifies a person from any position of public office. It's simply the same as saying that the endorsement of racism, fraud, or bribery, would disqualify him - except that child-killing is more serious than those.
John PiperWithout extended, concentrated prayer, the ministry of the Word withers. And when the ministry of the Word declines, faith (Rom. 10:17; Gal. 3:2, 5) and holiness (John 17:17) decline. Activity may continue, but life and power and fruitfulness fade away. Therefore, whatever opposes prayer opposes the whole work of ministry.
John Piper