End-stage liver disease refers to a liver that's failing, and a very high percentage of those livers are what we call cirrhotic, or the patient's liver has become cirrhotic, and what cirrhosis is, is the scarring of the liver tissue.

Pretty much everybody knows there are not enough organs for all of those patients who need to get transplants, and what happens is, is that organs are actually directed in liver transplantation to those patients who are the sickest. So the patients who have the greatest chance of dying in the next three months or so are the ones who get the priority for the liver transplant.

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When we think about living donor transplant, what we're banking on is the ability of the liver to regenerate itself. Now, it's not the same sort of regeneration we think about with the starfish where we cut off the arm and it grows a new arm. With the liver, what happens is the remaining liver gets bigger, and your body knows the size of the liver that it needs, and when it recognizes that there is not enough liver, it sends nutrients and signals to the liver and says "get bigger."

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We are always in awe of what the donors have done in terms of providing of themselves to the recipients. It really is a heroic act because people take on themselves not only a risk of death but also pain-and-suffering in order for their loved one to get the benefit of the liver transplant.

If we had enough cadaver organs to go around we wouldn't do living donor liver transplants because one is we don't want to put a donor at risk, but the second is that it's a more difficult surgery for the recipient because you're getting a piece of a liver rather than a whole liver. It takes you longer to recover, and it has more complications related to where we sew together the blood vessels and the bile ducts.