[Cannery Row's] inhabitants are, as the man once said, 'whores, pimps, gamblers, and sons of bitches,' by which he meant everybody. Had the man looked through another peephole he might have said, 'saints and angels and martyrs and holy men,' and he would have meant the same thing.

I have taken as much as six years to prepare a book for writing. There is such a delirium of effort in the production of a book; it's like childbirth. And, like childbirth, one forgets the pains immediately so that when you come to write another one you dare to take it up again. Some precious anesthesia sees you through.

Socialism never took root in America because the poor see themselves not as an exploited proletariat but as temporarily embarrassed millionaires.

I ought to of shot that dog myself, George. I shouldn't ought to of let no stranger shoot my dog.

All war is a symptom of man's failure as a thinking animal.

Men do change, and change comes like a little wind that ruffles the curtains at dawn, and it comes like the stealthy perfume of wildflowers hidden in the grass. Change may be announced by a small ache, so that you think you're catching cold. Or you may feel a faint disgust for something you loved yesterday. It may even take the form of a hunger that peanuts won't satisfy. Isn't overeating said to be one of the strongest symptoms of discontent. And isn't discontent the lever of change?

Intention, good or bad, is not enough.