His tiredness hurt so much it kept him awake.

Depression, when it's clinical, is not a metaphor. It runs in families, and it's known to respond to medication and to counseling. However truly you believe there's a sickness to existence that can never be cured, if you're depressed you will sooner or later surrender and say: I just don't want to feel bad anymore. The shift from depressive realism to tragic realism, from being immobilized by darkness to being sustained by it, thus strangely seems to require believing in the possibility of a cure.

Expecting a novel to bear the weight of our whole disturbed society—to help solve our contemporary problems—seems to me a peculiarly American delusion. To write sentences of such authenticity that refuge can be taken in them: isn't this enough? Isn't it a lot?

It's healthy to say uncle when your bone's about to break.

I guess my life hasn’t always been happy, or easy, or exactly what I want. At a certain point, I just have to try not to think too much about certain things, or else they’ll break my heart.

Brooklyn was like Philadelphia made better by its proximity to Manhattan.

If you're interested in how people behave, if you're interested in the way they talk about themselves, the way the conceive of themselves, it's very hard to ignore drugs nowadays, because that is so much part of the conversation.