There's something so scary about trying out new material and being completely comfortable jumping into the abyss with a comedic idea.

Nobody's going to like my next movie because they liked Trainwreck [2015]. It has to work on its own, and that keeps it really scary.

If we really talked about what's wrong with you, you'd need a 7-1/2-hour movie and nobody would know what category to put it in!

I'm always begging people like James Brooks and Cameron Crowe to come to screenings, to see what they make of it, and they're always ridiculously helpful. They also keep me brave enough to commit to what I'm trying to do. They can be great cheerleaders for risk-taking.

I wanted to see how funny I could be without making the choice that every 10 minutes something big and visual had to happen.

College is the reward for surviving high school. Most people have great fun stories from college and nightmare stories from high school.

I've come to believe that the simpler the title, the better. Whenever I try to get cute with it, it seems to be a problem but if it's just The 40-Year-Old Virgin, people seem to know what they're in for.