The metaphysical doctrine of determinism simply asserts that all events in this world are fixed, or unalterable, or predetermined. It does not assert that they are known to anybody, or predictable by scientific means. But it asserts that the future is as little changeable as is the past. Everybody knows what we mean when we say that the past cannot be changed. It is in precisely the same sense that the future cannot be changed, according to metaphysical determinism.
Karl PopperOur aim as scientists is objective truth; more truth, more interesting truth, more intelligible truth. We cannot reasonably aim at certainty. Once we realize that human knowledge is fallible, we realize also that we can never be completely certain that we have not made a mistake.
Karl PopperPhilosophy is a necessary activity because we, all of us, take a great number of things for granted, and many of these assumptions are of a philosophical character; we act on them in private life, in politics, in our work, and in every other sphere of our lives -- but while some of these assumptions are no doubt true, it is likely, that more are false and some are harmful. So the critical examination of our presuppositions -- which is a philosophical activity -- is morally as well as intellectually important.
Karl Popper