From a public health point of view, still the overwhelming problem is that people are not treated enough for depression; depression remains under treated.

No pill can help me deal with the problem of not wanting to take pills; likewise, no amount of psychotherapy alone can prevent my manias and depressions. I need both. It is an odd thing, owing life to pills, one's own quirks and tenacities, and this unique, strange, and ultimately profound relationship called psychotherapy

I, quite literally, woke up from a coma, from having tried to kill myself and it was very clear to me what my psychiatrist had been saying for years. The choice is not between a drug that has side effects or not, life is not ideal. Yes, your drug has side effects and yes if you don't take it you're going to die.

There is a particular kind of pain, elation, loneliness, and terror involved in this kind of madness. When you're high it's tremendous. The ideas and feelings are fast and frequent like shooting stars....But, somewhere, this changes. The fast ideas are far too fast, and there are far too many; overwhelming confusion replaces clarity. Everything previously moving with the grain is now against-you are irritable, angry, frightened, uncontrollable....It will never end, for madness carves its own reality.

Love, like life, is much stranger and far more complicated than one is brought up to believe.

One of the advantages of science is that one's work, ultimately, is either replicated or it is not.

It took me far too long to realize that lost years and relationships cannot be recovered. That damage done to oneself and others cannot always be put right again.