The pursuit of knowledge is an intoxicant, a lure that scientists and explorers have known from ancient times; indeed, exhilaration in the pursuit of knowledge is part of what has kept our species so adaptive.

No pill can help me deal with the problem of not wanting to take pills; likewise, no amount of psychotherapy alone can prevent my manias and depressions. I need both. It is an odd thing, owing life to pills, one's own quirks and tenacities, and this unique, strange, and ultimately profound relationship called psychotherapy

There is a particular kind of pain, elation, loneliness, and terror involved in this kind of madness. When you're high it's tremendous. The ideas and feelings are fast and frequent like shooting stars....But, somewhere, this changes. The fast ideas are far too fast, and there are far too many; overwhelming confusion replaces clarity. Everything previously moving with the grain is now against-you are irritable, angry, frightened, uncontrollable....It will never end, for madness carves its own reality.

Mania can be as terrifying as it gets. It is certainly as insane as one gets and so it's frightening when it gets out of control, but there are periods of mania when it can be extremely attractive.

Without science, there would be no such hope.

I wish I could explain it so someone could understand it. I'm afraid it's something I can't put into words. There's just this heavy, overwhelming despair - dreading everything. Dreading life. Empty inside, to the point of numbness. It's like there's something already dead inside. My whole being has been pulling back into that void for months. (81)

Curiosity, wonder, and passion are defining qualities of imaginative minds and great teachers...Restlessness and discontent are vital things... Intense experience and suffering instruct us in ways less intense emotions can never do.