Anybody who's had to contend with mental illness - whether it's depression, bipolar illness or severe anxiety, whatever - actually has a fair amount of resilience in the sense that they've had to deal with suffering already, personal suffering.

Somehow, like so many people who get depressed, we felt our depressions were more complicated and existentially based than they actually were.

Manic depression distorts moods and thoughts, incites dreadful behaviors, destroys the basis of rational thought, and too often erodes the desire and will to live.

The pursuit of knowledge is an intoxicant, a lure that scientists and explorers have known from ancient times; indeed, exhilaration in the pursuit of knowledge is part of what has kept our species so adaptive.

Looking at suicide—the sheer numbers, the pain leading up to it, and the suffering left behind—is harrowing. For every moment of exuberance in the science, or in the success of governments, there is a matching and terrible reality of the deaths themselves: the young deaths, the violent deaths, the unnecessary deaths

Knowledge is marvelous, but wisdom is even better.

The rites of passage in the academic world are arcane and, in their own way, highly romantic, and the tensions and unplesantries of dissertations and final oral examinations are quickly forgotten in the wonderful moment of the sherry afterward, admission into a very old club, parties of celebration, doctoral gowns, academic rituals, and hearing for the first time "Dr.," rather than "Miss" Jamison.