It's a roll of the dice in the movie business. I mean, every single movie is a roll of the dice. Any movie on paper could look like it's going to be fantastic. You know what I mean?

I was asked to be in the last two 'Harry Potter' films and I couldn't do it because I was busy filming 'Grey's Anatomy.

If a man comes up to me, I'm almost sure he's going to mention Rome, if it's a woman, it'll be 'Grey's Anatomy.'

Grey's' is just a machine. I wasn't really prepared for the epic nature of how popular the show is.

I've done movies that I've been advised not to do. 'Dog Soldiers,' the movie I did 11 years ago now, I remember my agent at the time was like, 'You shouldn't do that. It's a weird film about werewolves,' and it became a cult hit.

I actually love working with accents. I don't know, something about it unlocks something in me. It makes me concentrate on getting into character a little more, helps me find a focus.

I live in LA so I worry my kids aren't that connected to Britain, I suppose I don't want them to become American kids. We try to get back three or four times a year. When they go to school they speak with a British-American accent but when they come home to us they go back to their British accent, so I can deal with that.