I understand that actors lose their looks, they change over time, but people don't lose their talent. I think that, as people get older and the people who make the decisions get older, they don't like hiring people much older than them because it reminds them of their fathers, and they don't like telling people older than them what to do. It makes them uncomfortable. I think that happens a lot.

I always had to rely on humor and sarcasm. And when I started having kids, that doesn't work with kids. Kids don't understand sarcasm, and they certainly don't understand my humor.

I would go to these 'Supernatural' conventions because, well, one, it's like going to your own version of Disneyland. You're adored for an hour or whatever, and then you walk out and you're nobody again, but, boy, when you're there, it must be what it's like to be Brad Pitt all day, you know? You're the best thing going. And it pays pretty well, too! But I was concurrently loved and hated by everybody, because the suspension of disbelief is, uh, pretty high among 'Supernatural' fans.

To be an actor, a lot of times it's a strange combination of high confidence and low self-esteem. Which is a weird combination to have, but I think it's sort of very common among actors.

I can't emphasize the immediate panic that would set in when I had to audition. I can't believe I did it.

I am not a member of the chamber of commerce for show business, believe me, but there are some really good people in the business, and [Tom] Hanks has this everyman decency onscreen, but he actually is that guy.

I was probably 34 when I got my first on-camera acting job, and it was through a friend of mine, who was working as a writer on the show, and I've never been more frightened in my life.