The greatest achievements in the science of this [twentieth] century are themselves the sources of more puzzlement than human beings have ever experienced. Indeed, it is likely that the twentieth century will be looked back at as the time when science provided the first close glimpse of the profundity of human ignorance. We have not reached solutions; we have only begun to discover how to ask questions.

In the fields I know best, among the life sciences, it is required that the most expert and sophisticated minds be capable of changing course - often with a great lurch - every few years.

I would send the complete works of Johann Sebastian Bach into outer space on the Voyager spacecraft. But that would be boasting.

Viewed from the distance of the moon, the astonishing thing about the earth, catching the breath, is that it is alive. The photographs show the dry, pounded surface of the moon in the foreground, dry as an old bone. Aloft, floating free beneath the moist, gleaming, membrane of bright blue sky, is the rising earth, the only exuberant thing in this part of the cosmos.

I agree that you might clone some people who would look amazingly like their parental cell donors, but the odds are that they'd be almost as different as you or me, and certainly more different than any of today's identical twins.

Good applied science in medicine, as in physics, requires a high degree of certainty about the basic facts at hand, and especially about their meaning, and we have not yet reached this point for most of medicine.

We still think of human disease as the work of an organized, modernized kind of demonology, in which the bacteria are the most visible and centrally placed of our adversaries. We assume that they must somehow relish what they do.