I know that sounds really extreme, but if you just look at the history, you will find Harry Anslinger [first U.S. commissioner of the Bureau of Narcotics] going on about satanic swing and how reefer will make black people think they're as good as white people - which to him, obviously, was a very horrible outcome. This is the basis of our drug laws.

The best outcomes that are seen for therapy intervention and for other psychological interventions is where the therapist really connects and the person really feels understood. That matters often even more than the technique.

When President Nixon declared war on drugs on June 17, 1971, about 110 people per 100,000 in the population were incarcerated. Today, we have 2-3 million prisoners: 743 people per 100,000 in the population. The U.S. has 5% of the world's population, but 25% of its prisoners. As Senator Jim Webb once put it, Either we are home to the most evil people on earth or we are doing something different and vastly counterproductive.

Do we really want to base our 21st-century policy on what the colonialist preferred at a certain time in history, not at all based on health or what the preferences of different cultures might be? That's just ridiculous.

There is a safe, nontoxic drug called naloxone that can instantly reverse opioid overdose and prevent most of these deaths. But the drug war interferes with saving overdose victims in two ways: first, because witnesses to overdose fear prosecution, they often don't call for help until it's too late. Second, because the drug war supports the belief that making naloxone available over-the-counter or with opioid prescriptions would encourage drug use, the antidote is available only through harm reduction programs like needle exchanges or in some state programs aimed at drug users.

We absolutely should legalize marijuana.

Punishment by definition isn't going to help. So what you need to do is to help people to change and recover is to help them find different areas of passion and help them find better ways of coping. Because about 50 percent of people with addiction have a preexisting mental illness, about two-thirds have had some type of severe trauma during childhood, and they are not using to the point where they're risking their lives because it's fun. They're doing something to help them cope.