I think loss of loved ones is the hardest blow in life.

I think that there's got to be a comic gene in some way, but it's so much about it is how you grow up.

When I look back at those pictures of my mother performing - and listen to her recordings - it makes me sad to think that all of that joy she found in her work came to an end. I wish she hadn't had to make that sacrifice, even if it was for the benefit of my father and siblings and me.

As much success came to him, my father stayed true to his promise. He built the hospital to help the most helpless children with catastrophic illnesses.

Every child deserves a chance at a life filled with love, laughter, friends and family. We are working to find the cures that will give these youngsters a fighting chance. When a child or parent faces an uncertain disease like cancer, they can find hope at St. Jude - a place where miracles can and do happen.

Laughter is important, not only because it makes us happy, it also has actual health benefits. And that's because laughter completely engages the body and releases the mind. It connects us to others, and that in itself has a healing effect.

One of the many reasons I love living in New York is that we get a front row seat to the innumerable thrills that take place here - from conventions and awards shows, to parades and U.N. assemblies. But my favorite New York tradition is the annual New Year's Eve ball-drop on Times Square.