I'm a technological optimist in that I do believe that technology will provide solutions that will allow the world in 2050 to support 9 billion people at an acceptable standard of living. But I'm a political pessimist in that I am concerned about whether the science will be appropriately applied.

There may be organic life out there, or maybe machines created by long-dead civilizations, but any signals, even if they are difficult to decode, would tell us that the concepts of logic and physics are not limited to the hardware in human skulls, and will transform our view of the universe.

It will not be humans who watch the sun's demise, six billion years from now. Any creatures that then exist will be as different from us as we are from bacteria or amoebae.

In this century, not only has science changed the world faster than ever, but in new and different ways. Targeted drugs, genetic modification, artificial intelligence, perhaps even implants into our brains - may change human beings themselves.

Absence of evidence is not evidence of absence.

To ensure continuing prosperity in the global economy, nothing is more important than the development and application of knowledge and skills.

Once the threshold is crossed when there is a self-sustaining level of life in space, then life's long-range future will be secure irrespective of any of the risks on Earth. Will this happen before our technological civilization disintegrates, leaving this as a might-have-been? Will the self-sustaining space communities be established before a catastrophe sets back the prospect of any such enterprise, perhaps foreclosing it forever? We live at what could be a defining moment for the cosmos.