... it is because one can build a compelling set of arguments - informed by science and thoroughly compatible with it - that to believe in anything despite the complete lack of evidence is, in fact, irrational.

If a theory purports to explain everything, then it is likely not explaining much at all.

I believe Stoicism can help anyone who takes it seriously and begins to practice it. It will help them flourish because it will provide them with a compass for navigating life, a general, flexible, framework to set priorities, and a set of techniques to achieve serenity and equanimity.

"Fate permitting" is a standard Stoic phrase meant to remind ourselves that planning things is up to us, but the ultimate outcomes are not under our control. It helps us to develop an attitude of equanimity toward the universe. We should very much try to change things for the better, that's the whole point of the Stoic discipline of action.

... it is because one can build a compelling set of arguments - informed by science and thoroughly compatible with it - that to believe in anything despite the complete lack of evidence is, in fact, irrational.

The Stoic discipline of action, which is connected to the virtue of justice, says that we ought to treat others fairly and we should engage in social and political activity. This is further supported by the Stoic idea of cosmopolitanism, and by the famous "circles of concern" identified by Hierocles, who counseled that we should refer to other people as brothers and sisters, to constantly remind ourselves that we are members of the same human family.

The downside of skepticism: it can easily turn into an arrogant position of a priori rejection of any new phenomenon or idea, a position that is as lacking in critical thinking as the one of the true believer, and that simply does not help either science or the public at large.