There's always failure. And there's always disappointment. And there's always loss. But the secret is learning from the loss, and realizing that none of those holes are vacuums.

I believe that the majority of times the scale tilts toward the good. It's this amazing thing that rolls on and if we get in the flow of it, that's God. And if we fight it, if we swim the other way, we're swimming away from the purest expression of this life.

After a year or so I really thought I was Howard Hughes. Here I was at eighteen years old, getting all these checks.

They did something once that slurred my speech, and I thought, "Oh, man, you're messing with my brain. It's freaking me out."

The moment I understood this - that my Parkinson's was the one thing I wasn't going to change - I started looking at the things I could change, like the way research is funded.

I wouldn't have wanted to miss the opportunity to make those three films that didn't do well. They were really important to me, and the things I learned doing them were important to me.

I mean, I enjoy my work as an actor. But to make a difference in people's lives through advocacy and through supporting research - that's the kind of privilege that few people will get, and it's certainly bigger than being on TV every Thursday for half an hour.