We're quite happy with our Big Bang description of cosmic origins. But actually, the Big Bang accounts for what happened only after the beginning. The beginning itself, and especially what happened before, remains the biggest mystery of all.

There was a transition going on - Baghdad being the intellectual capital of the world where major advances were made in agriculture and mathematics and engineering and medicine and astronomy, and then that all sort of collapsed. And I was trying to understand how such a intellectually fertile environment can lose its compass bearing. Because I think about the creative centers today - countries, or even regions. Will Silicon Valley always be as innovative? Will the United States be innovative, or will we become complacent?

We fail in even the simplest of all scientific observations-nobody looks up anymore.

We're talking about a being whose very existence challenges our own sense of priority in the universe.

Everything we do understand about the universe - the periodic table of elements, Einstein's laws, Newton's laws, all of chemistry, all of biology - that's 4 percent of the universe. We got to the moon on the 4 percent we do understand. We landed on Mars on the 4 percent we do understand. So the day we crack the nut of the rest of that 95 percent... Oh my gosh.

There is no true understanding of Biology without Chemistry. And there's no true understanding of Chemistry without Physics.

The history of exploration has never been driven by exploration. But Columbus himself was a discoverer. So was Magellan. But the people who wrote checks were not. They had other motivations. And there's Columbus - he couldn't even get Italy to pay for his voyage so he has to go to Spain.