For healthy adult people, the really big thing we can foresee are ways of intervening in the ageing process, either by slowing or reversing it.
Nick BostromHow can we trace out the links between actions that people take today and really long-term outcomes for humanity - outcomes that stretch out indefinitely into the future? I call this effort macrostrategy - that is, to think about the really big strategic situation for having a positive impact on the long-term future. There's the butterfly effect: A small change in an initial condition could have arbitrarily large consequences.
Nick BostromThe first ultraintelligent machine is the last invention that man need ever make, provided that the machine is docile enough to tell us how to keep it under control.
Nick BostromFar from being the smartest possible biological species, we are probably better thought of as the stupidest possible biological species capable of starting a technological civilization - a niche we filled because we got there first, not because we are in any sense optimally adapted to it.
Nick Bostrom