You will find true success and happiness if you have only one goal, there really is only one, and that is this: to fulfill the highest most truthful expression of yourself as a human being. You want to max out your humanity by using your energy to lift yourself up, your family and the people around you. Theologian Howard Thurman said it best. He said, “Don’t ask yourself what the world needs. Ask yourself what makes you come alive and then go do that, because what the world needs is people who have come alive.”

To kick things off, [television show host Andy Cohen] asked the last time Winfrey had smoked marijuana. 'Uh ... 1982,' Winfrey replied. 'Let's hang out after the show,' Cohen joked. 'Okay,' Winfrey laughed. 'I hear it's gotten better.'

I don't want to have to get the lesson of losing [things like health and moving about freely] to appreciate what it was.

All my life I have always known I was born to greatness.

I believe everyday your life speaks to you - through every experience, through the people you meet, and even through pain, fear and self-doubt.

Everybody has a calling. And your real job in life is to figure out as soon as possible what that is, who you were meant to be, and to begin to honor that in the best way possible for yourself.

As you become more clear about who you really are, you'll be better able to decide what is best for you - the first time around.