Large companies and government agencies have a lot to protect and therefore are not willing to take big risks. A large company taking a risk can threaten its stock price. A government agency taking a risk can threaten congressional investigation.

By 2020 the U.S. will be short 91,000 doctors. There's no way we can educate enough doctors to make up that shortfall, and other countries are far worse off.

Small teams driven by their passion with a clear focus can do extraordinary things. Things that only large corporations and governments could do in the past.

One of my goals is to reinvent philanthropy.

Many have built their careers buttressing the status quo, reinforcing what theyve already accomplished, and resisting the radical thinking that can topple their legacy - not exactly the attitude you want when trying to drive innovation forward.

The paradigm I want to change is that, you can have a car that is beautiful, manufacturable, affordable, safe, fast, and oh, by the way, does 100 mpg, or its energy equivalent. Why wouldn't you?

The quality of your life is a function of who you go through life with.