Twice in my life I have spent two weary and scientifically profitless years seeking evidence to corroborate dearly loved hypotheses that later proved to be groundless; times such as these are hard for scientists-days of leaden gray skies bringing with them a miserable sense of oppression and inadequacy.

No scientist is admired for failing in the attempt to solve problems that lie beyond his competence. ... Good scientists study the most important problems they think they can solve. It is, after all, their professional business to solve problems, not merely to grapple with them.

The bells which toll for mankind are - most of them, anyway - like the bells of Alpine cattle; they are attached to our own necks, and it must be our fault if they do not make a cheerful and harmonious sound.

Twice in my life I have spent two weary and scientifically profitless years seeking evidence to corroborate dearly loved hypotheses that later proved to be groundless; times such as these are hard for scientists-days of leaden gray skies bringing with them a miserable sense of oppression and inadequacy.

The art of research [is] the art of making difficult problems soluble by devising means of getting at them.

Scientists who think science consists of unprejudiced data-gathering without speculation are merely cows grazing on the pasture of knowledge.

The case I shall find evidence for is that when literature arrives, it expels science.