It would be nonsense to say that it was not in the interests of a stone to be kicked along the road...A stone has no interests because it cannot suffer. The capacity for suffering and enjoyment is, however, not only necessary, but also sufficient for us to say that a being has interests - at an absolute minimum, an interest in not suffering. A mouse, for example, does have an interest in not being kicked along the road because it will suffer if it is.

If possessing a higher degree of intelligence does not entitle one human to use another for his or her own ends, how can it entitle humans to exploit non-humans?

The most callous, stupid things were done just because regulations required them...It was not until 1983, for example, that U.S. federal agencies stated that substances known to be caustic irritants such as lye, ammonia, and oven cleaners, did not need to be tested on the eyes of conscious rabbits.

There has been opposition to experimenting on animals for a long time. This opposition has made little headway because experimenters, backed by commercial firms that profit by supplying laboratory animals and equipment, have been able to convince legislators and the public that opposition comes from uninformed fanatics who consider the interests of animals more important than the interests of human beings.

Once we ask why it should be that all human beings - including infants, the intellectually disabled, criminal psychopaths, Hitler, Stalin, and the rest - have some kind of dignity or worth that no elephant, pig, or chimpanzee can ever achieve, we see that this question is as difficult to answer as our original request for some relevant fact that justifies the inequality of humans and other animals.

If a being suffers there can be no moral justification for refusing to take that suffering into consideration. No matter what the nature of the being, the principle of equality requires that its suffering be counted equally with the like suffering - insofar as rough comparisons can be made - of any other being. So the limit of sentience is the only defensible boundary of concern for the interests of others. To mark this boundary by some other characteristic like intelligence or rationality would be to mark it in an arbitrary manner. Why not choose some other characteristic, like skin color?

Sci-fi is often a metaphor. I think it's more the themes and questions that science fiction raises rather than the exact predictions that should guide us.