The biggest secret in venture capital is that the best investment in a successful fund equals or outperforms the entire rest of the fund combined.

We cannot take for granted that the future will be better, and that means we need to work to create it today.

We need more pessimism that the future might be a lot worse, and we need more optimism that the future might be better.

There are quite a lot of people who think my aspirations are not possible. That's a good thing. We don't need to really worry about these people very much, because since they don't think it's possible they won't take us very seriously- and they will not actually try to stop us until it's too late.

I do think Bitcoin is the first [encrypted money] that has the potential to do something like change the world.

Beginning with brand rather than substance is dangerous.

Anti-aging is an extremely under-explored field.