Anti-aging is an extremely under-explored field.

American government is not dominated by engineers, it is dominated by lawyers. Engineers are interested in substance and building things; lawyers are interested in process and rights and getting the ideology correctly blended. And so there is sort of no really concrete plan for the future.

It's a horribly mismanaged company-probably a lot of pot smoking going on there.

Competition is overrated. In practice it is quite destructive and should be avoided wherever possible. Much better than fighting for scraps in existing markets is to create and own new ones.

People working on bigger ideas on a more protracted timeline will be more on the stealth side. They aren’t releasing new PR announcements every day. The bigger the secret and the likelier it is that you alone have it, the more time you have to execute. There may be far more people going after hard secrets than we think.

There's been a lot companies that have shown "zero to one" kind of growth in the computer, internet software age. Facebook and Google are zero to one companies. Apple's iPhone was the first smartphone that really works, and of course, then you scale it horizontally, but the vertical component was really critical. Space X would also be one.

Value investors look at cash flows. If a company can maintain present cash flows for 5 or 6 years, it’s a good investment. Investors then just hope that those cash flows - and thus the company’s value - don’t decrease faster than they anticipate.