Mathematics is an interesting intellectual sport but it should not be allowed to stand in the way of obtaining sensible information about physical processes.

If you don't work on important problems, it's not likely that you'll do important work.

A parable: A man was examining the construction of a cathedral. He asked a stone mason what he was doing chipping the stones, and the mason replied, "I am making stones." He asked a stone carver what he was doing. "I am carving a gargoyle." And so it went, each person said in detail what they were doing. Finally he came to an old woman who was sweeping the ground. She said. "I am helping build a cathedral." ...Most of the time each person is immersed in the details of one special part of the whole and does not think of how what they are doing relates to the larger picture.

Perhaps the central problem we face in all of computer science is how we are to get to the situation where we build on top of the work of others rather than redoing so much of it in a trivially different way.

One of the characteristics of successful scientists is having courage.

If the prior distribution, at which I am frankly guessing, has little or no effect on the result, then why bother; and if it has a large effect, then since I do not know what I am doing how would I dare act on the conclusions drawn?

Science is composed of laws which were originally based on a small, carefully selected set of observations, often not very accurately measured originally; but the laws have later been found to apply over much wider ranges of observations and much more accurately than the original data justified.