A few atoms added here, subtracted there, is all it takes to make the difference between male and female sex characteristics, between a harmless molecule and a deadly addictive one.
Roald HoffmannOne day I discovered that one could get the barrier to internal rotation in ethane approximately right using this method. This was the beginning of my work on organic molecules.
Roald HoffmannNot every collision, not every punctilious trajectory by which billiard-ball complexes arrive at their calculable meeting places lead to reaction. ... Men (and women) are not as different from molecules as they think.
Roald HoffmannAlan Rocke's Image and Reality does so many things vividly and convincingly: it shows how visual images led chemistry step by step to the reality of the microscopic world; how simple portrayals of the logic of substitution and combination were reified; brings to our attention the imaginative, neglected work of Williamson and Kopp; and takes a critical look at Kekule's daydream. And it beautifully delineates the essential place the imagination has in science. A rewarding, lively picture of chemistry in formation.
Roald HoffmannFrom a chemist's point of view, the surface or interior of a starโฆis boringโthere are no molecules there.
Roald Hoffmann