That chemistry that we had [with Fred Savage] is very, very hard to find. We were lucky to have those 22 episodes [of The Grinder]. I'm unendingly proud of it.

You show me someone who's led a perfect life and I'll show you a dullard.

I had to learn American sign language. And I did stuff in it, stuff that was just for me and was fun, that I don't think anyone would ever notice.

Sam Seaborn is the best character that's ever been written for me, certainly. By far. And it's a timeless show [The West Wing], one that's having another resurgence now, with people so in an uproar politically.

In the business of acting, those are the actors that make the trains run on time, you know? There's nothing without them.

I know, there are so many great lines [in Tommy Boy]. People say to me, "Did you eat paint chips for a living?" Or, "These shoes are worth more than your life." And the one I get all the time is, "Brothers don't shake hands, brothers gotta hug!"

There's an argument that maybe [The Grinder] was better suited for streaming or cable. I don't know. I still like to think there's a place for smart, subversive, original comedies on networks.