He is only fantastical that is not in fashion.

Diseases crucify the soul of man, attenuate our bodies, dry them, wither them, rivel them up like old apples, make them as so many Anatomies.

Certainty is not biologically possible. We must learn (and teach our children) to tolerate the unpleasantness of uncertainty. Science has given us the language and tools of probabilities. We have methods for analyzing and ranking opinion according to their likelihood of correctness. That is enough.

Temperance is a bridle of gold; he, who uses it rightly, is more like a god than a man.

He is only fantastical that is not in fashion.

Our mental limitations prevent us from accepting our mental limitations.

Good science requires distinguishing between "felt knowledge" and knowledge arising out of testable observations. "I am sure" is a mental sensation, not a testable conclusion. Put hunches, gut feelings, and intuitions into the suggestion box. Let empiric methods shake out the good from bad suggestions.