Out of too much learning become mad.

We want to be known for having original ideas, inspired hunches, and gut feelings that make a difference. Indeed, a "well-honed sixth sense"' is considered a measure of the good clinician. But being a good doctor also requires sticking with the best medical evidence, even if it contradicts your personal experience. We need to distinguish between gut feeling and testable knowledge, between hunches and empirically tested evidence.

Cookery is become an art, a noble science; cooks are gentlemen.

Certainty is not biologically possible. We must learn (and teach our children) to tolerate the unpleasantness of uncertainty. Science has given us the language and tools of probabilities. We have methods for analyzing and ranking opinion according to their likelihood of correctness. That is enough.

Certainty and similar states of ‘knowing what we know’ arise out of involuntary brain mechanisms that, like love or anger, function independently of reason.

Diseases crucify the soul of man, attenuate our bodies, dry them, wither them, rivel them up like old apples, make them as so many Anatomies.

Good science requires distinguishing between "felt knowledge" and knowledge arising out of testable observations. "I am sure" is a mental sensation, not a testable conclusion. Put hunches, gut feelings, and intuitions into the suggestion box. Let empiric methods shake out the good from bad suggestions.