What happened in the milliseconds before a behavior to cause it? That's in the neurobiological realm.

Depression is not generalized pessimism, but pessimism specific to the effects of one's own skilled action.

The frontal cortex is an incredibly interesting part of the brain - ours is proportionately bigger and/or more complex than in any other species.

Finish this lecture, go outside, and unexpectedly get gored by an elephant, and you are going to secrete glucocorticoids. There's no way out of it. You cannot psychologically reframe your experience and decide you did not like the shirt, here's an excuse to throw it out - that sort of thing.

We're getting along so well; I trust you so much for this one second that I'm going to let you yank on me.

On an incredibly simplistic level, you can think of depression as occurring when your cortex thinks an abstract thought and manages to convince the rest of the brain that this is as real as a physical stressor.

Perhaps most excitingly, we are uncovering the brain basis of our behaviors - normal, abnormal and in-between. We are mapping a neurobiology of what makes us us.