If I had to define a major depression in a single sentence, I would describe it as a "genetic/neurochemical disorder requiring a strong environmental trigger whose characteristic manifestation is an inability to appreciate sunsets.
Robert M. SapolskyBrains distinguish between an Us and a Them in a fraction of a second. Subliminal processing of a Them activates the amygdala and insular cortex, brain regions that are all about fear, anxiety, aggression, and disgust.
Robert M. SapolskyBut if you get chronically, psychosocially stressed, you're going to compromise your health. So, essentially, we've evolved to be smart enough to make ourselves sick.
Robert M. SapolskyI had never planned to become a savanna baboon when I grew up; instead, I had always assumed I would become a mountain gorilla.
Robert M. Sapolsky