... no scientific worker has a fixed level of significance at which from year to year, and in all circumstances, he rejects hypotheses; he rather gives his mind to each particular case in the light of his evidence and his ideas.
Ronald FisherWe may consequently state the fundamental theorem of Natural Selection in the form: The rate of increase in fitness of any organism at any time is equal to its genetic variance in fitness at that time.
Ronald FisherIt was Darwin's chief contribution, not only to Biology but to the whole of natural science, to have brought to light a process by which contingencies a priori improbable, are given, in the process of time, an increasing probability, until it is their non-occurrence rather than their occurrence which becomes highly improbable.
Ronald FisherIf one in twenty does not seem high enough odds, we may, if we prefer it, draw the line at one in fifty (the 2 per cent. point), or one in a hundred (the 1 per cent. point). Personally, the writer prefers to set a low standard of significance at the 5 per cent. point, and ignore entirely all results which fail to reach this level. A scientific fact should be regarded as experimentally established only if a properly designed experiment rarely fails to give this level of significance.
Ronald Fisher