One of the responsibilities faced by the Environmental Genome Project is to provide the science base upon which society can make better informed risk management decisions.

One of the responsibilities faced by the Environmental Genome Project is to provide the science base upon which society can make better informed risk management decisions.

While the Environmental Genome Project does not seek to assign allele frequencies, we are aware of the importance of accurate allele frequency estimates for future epidemiologic studies and the large sample sizes such estimates will require.

To maximize our potential to enhance our health and our knowledge, we should remain open to new understanding and evolving technology or resources that might inspire a change in our approach to these important questions.

Compulsive modernization is the insatiable desire to change and grow.

It is important to consider whether the sample size selected by the Environmental Genome Project will provide sufficient power to discover most alleles relevant to gene-environment interactions.

There is no doubt that environmentally related diseases will continue to pose problems in the future.