Nobody knows what will work until they try it. Some of comics' biggest success stories in recent years have explored subjects that no one was writing about at the time - stories no one had any reason to think would succeed. My advice? Write what you want to read. You'll have more fun doing it - and if all else fails, you'll always have at least one loyal reader.
Scott McCloudI've always been very forward-looking, and it was actually kind of difficult to turn my gaze backwards to look at comics history.
Scott McCloudAs I see it, mainstream comics now speak only to the hardcore few who stayed; conversing in a weird, garbled, visual pig latin only they can understand - rendering the term 'mainstream' a hollow joke - while the true mainstream, the other 99.9% of the populace, find enjoyment elsewhere.
Scott McCloud