Finally I want to say this: If you are a kid and you are out there and you are chubby and not so cute and nerdy and shy and invisible and in pain, whatever your race, whatever your gender, whatever your sexual orientation, I’m standing here to tell you: You are not alone. Your tribe of people, they are out there in the world. Waiting for you.

When you help make people healthier, it makes the nation healthier, it makes the world healthier, it makes the economy healthier.

I never, ever pay attention to the ratings. I stopped paying attention to the ratings somewhere around season two or three of Grey's. It's something I have no control over, so I don't even pay attention.

My parents created a world in which the only ­barrier to your success is your own imagination.

At the end of the day, when it comes down to it, all we really want is to be close to somebody. So this thing where we all keep our distance and pretend not to care about each other, it's usually a load of bull. So we pick and choose who we want to remain close to, and once we've chosen those people, we tend to stick close by. No matter how much we hurt them. The people that are still with you at the end of the day, those are the ones worth keeping. And sure, sometimes close can be too close. But sometimes, that invasion of personal space, it can be exactly what you need.

Finally I want to say this: If you are a kid and you are out there and you are chubby and not so cute and nerdy and shy and invisible and in pain, whatever your race, whatever your gender, whatever your sexual orientation, I’m standing here to tell you: You are not alone. Your tribe of people, they are out there in the world. Waiting for you.

I remember saying, very almost jokingly, I'm going to take over the world through television, that's my plan. And I said it to my agent, and I said it to my friends, and I said it to myself.