Im married, so I tend not to hit on every girl.

It's always nice when someone says that they don't realize it's me on screen, but it would be strange to enter a one story while thinking of another character I do, which is completely different.

I always honestly dreamed of coming to Second City in Chicago, although I've never even been there to see a show. But I did a ton of sketch comedy at the Second City in LA, which (at the time, in a different location) wasn't really a theater, it was just a space where you took some classes.

I wanted to move on. I wanted to do acting. The next thing I did after [MADtv] was a good hybrid of that. I did this show with Bob Odenkirk and Derek Waters (creator of Comedy Central's "Drunk History") and it was a little homegrown thing that we shot and then we sold it to HBO. We made a pilot and HBO didn't pick it up, but then we made all these webisodes. This was before streaming stuff online made any sense. (The episodes are available on YouTube). Nobody even knew how to watch things on the internet.

I did not want to be the accompanist to an operatic star. But I was at a very high level for a 16-year-old, and I maintained that. So really good, but more impressive than classically trained. So I had to take a crash course in classical technique because I really wanted to get away with playing this character [in Florence Foster Jenkins] without people saying, "That's not really accurate."

There are bits at the table read that destroy, so much so that we can't wait to do it in taping. And then, no reaction. And then there are times when I can't get the right read on a line in rehearsal, and then the audience howls at it. The strange thing is I still don't know why it happens like that. It's not like afterwards I think, 'Now I know why that worked!'

There's also these moments when you're like, oh, I really want to do different things. Not instead of this show [The Big Bang Theory]. It's just a hunger to do something else, too.