There's no real escape from the work, but in some ways, if you're as obsessive as I am, it's a sweet little thing we've figured out. You bring your work home and you work 24 hours a day, but it's good.

I wanted to come to Chicago. I also wanted to do "Saturday Night Live." And then I got to a place where I didn't want to do those things anymore.For the sketch comedy thing, I got cast on "MADtv," and that will kill any man's desire to do comedy.

To me the ambiguity is, maybe our perception of ourselves is always going to be different than somebody else's perception. There will always be that disparity.

When you have this long of a run [in The Big Bang Theory], you don't have to have something happen every episode. Like, Sheldon lost his virginity last season and in the first season he didn't even like girls. So I feel like you can earn that stuff. And that is really fun, because you get to find new layers. It's a testament to the writing.

We all have those dreams of going back in time and seeing what it was like when our parents were younger. Maybe we don't all have that dream. I don't know. Getting to role play or step back to a different moment in time and see things through a different lens is something that resonated with me, for sure. We don't get to do that, generally, but when the right neurological disorder lines up with the right unstable woman, that moment presents itself. Getting to know where we come from is a really profound way of getting to look at who we are.

I wouldn't wear turtlenecks. That I'm not envious of. But who knows? I might sneak out a few things and hope and pray that no one says, 'Hey, didn't you wear that when you were playing an enormous geek on TV?'

That is what's disconcerting about working on the show, you can't seem to get an instinct about what works and what doesn't. It happens a lot, and in different ways.