I met a bunch of people and they said, "We're gonna do a show [Second City]." So we would buy the theater out and do a show, and we did that for five years and we ended up becoming popular. It was before sketch comedy was hipster-time - when you would hand out a flier, people would roll their eyes. Now it's kind of cool.

I came in ["MADtv"] kind of late in the season. Some of the producers didn't want me but the network did. It was all (messed up) from the beginning.

There are bits at the table read that destroy, so much so that we can't wait to do it in taping. And then, no reaction. And then there are times when I can't get the right read on a line in rehearsal, and then the audience howls at it. The strange thing is I still don't know why it happens like that. It's not like afterwards I think, 'Now I know why that worked!'

We all have those dreams of going back in time and seeing what it was like when our parents were younger. Maybe we don't all have that dream. I don't know. Getting to role play or step back to a different moment in time and see things through a different lens is something that resonated with me, for sure. We don't get to do that, generally, but when the right neurological disorder lines up with the right unstable woman, that moment presents itself. Getting to know where we come from is a really profound way of getting to look at who we are.

Generally people are nice, but it's so weird that it has made me more cautious. Just like anyone else, I like looking around at my environment, but now as I walk down the street I tend to look down.

When you have this long of a run [in The Big Bang Theory], you don't have to have something happen every episode. Like, Sheldon lost his virginity last season and in the first season he didn't even like girls. So I feel like you can earn that stuff. And that is really fun, because you get to find new layers. It's a testament to the writing.

There's no real escape from the work, but in some ways, if you're as obsessive as I am, it's a sweet little thing we've figured out. You bring your work home and you work 24 hours a day, but it's good.