No man can ever end with being superior who will not begin with being inferior.

The longer I live, the more I am convinced that the apothecary is of more importance than Seneca; and that half the unhappiness in the world proceeds from little stoppages; from a duct choked up, from food pressing in the wrong place, from a vexed duodenum, or an agitated pylorus.

Poverty is no disgrace to a man, but it is confoundedly inconvenient.

Have the courage to be ignorant of a great number of things, in order to avoid the calamity of being ignorant of everything.

A great deal of talent is lost to the world for the want of a little courage. Every day sends to their graves a number of obscure men who have only remained obscure because their timidity has prevented them from making a first effort; and who, if they could only have been induced to begin, would in all probability have gone great lengths in the career of fame.

[T]he 47th proposition in Euclid might now be voted down with as much ease as any proposition in politics; and therefore if Lord Hawkesbury hates the abstract truths of science as much as he hates concrete truth in human affairs, now is his time for getting rid of the multiplication table, and passing a vote of censure upon the pretensions of the hypotenuse.

People who love only once in their lives are shallow people. What they call their loyalty, and their fidelity, I call either the lethargy of custom, or their lack of imagination